Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.
نویسندگان
چکیده
Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin plummet early during adulthood in mice, monkeys, and humans of both genders. Exploring these observations revealed that osteocalcin signaling in myofibers is necessary for adaptation to exercise by favoring uptake and catabolism of glucose and fatty acids, the main nutrients of myofibers. Osteocalcin signaling in myofibers also accounts for most of the exercise-induced release of interleukin-6, a myokine that promotes adaptation to exercise in part by driving the generation of bioactive osteocalcin. We further show that exogenous osteocalcin is sufficient to enhance the exercise capacity of young mice and to restore to 15-month-old mice the exercise capacity of 3-month-old mice. This study uncovers a bone-to-muscle feedforward endocrine axis that favors adaptation to exercise and can reverse the age-induced decline in exercise capacity.
منابع مشابه
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
OBJECTIVE A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. METHODS We examined muscle mass and strength in mice lacking osteocalcin (Ocn-/-) or its re...
متن کاملEffect of Pilates Exercise Training on Serum Osteocalcin and Parathormone levels in inactive and overweight women
Introduction: Experimental evidence suggests positive effects of physical activity on skeletal mass. Biochemical markers determine the response rate of bone metabolism to physical activity. Therefore, the aim of this study was to investigate the effect of Pilates exercise training on serum osteocalcin and parathormone levels in inactive and overweight women. Methods: 28 healthy overweight wome...
متن کاملThe effect of resistance training and date pollen extract on bone tissue density and osteoblast cell proliferation in young male rats
Extended Abstract 1.Introduction One of the tissues that is affected by physical activity is bone. Bone is one of the tissues that needs to receive mechanical load to have normal function as a key factor in strengthening bone mass (2). Evidence shows that the mechanical load resulting from physical activity activates a set of proteins involved in the process of osteoblast activation and inhib...
متن کاملEffect of 8-week Aerobic Exercise on Undercarboxylated Osteocalcin and Beta Cell Function in Postmenopausal Women
ABSTRACT Background and Objective: The present study aims at investigating the possible effect of 8-week aerobic exercise on undercarboxylated osteocalcin and beta cell function in postmenopausal women. Methods: The study included 20 postmenopausal women with mean weight, height and b...
متن کاملStudy on the Effect of Alcoholic Extract of Flaxseed and Aerobic Exercise on Osteoporosis Parameters on Ovariectomized Rats
Background & Aims: Osteoporosis is a systemic skeletal disease associated with decreased bone mass and loss of bone tissue structure, resulting in increased susceptibility to fractures. Depending on the etiological factors, the disease may occur in primary (menopausal and aging) and secondary forms. One of the important etiologies of this disease is estrogen deficiency, in which estrogen defici...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell metabolism
دوره 23 6 شماره
صفحات -
تاریخ انتشار 2016